Publications - Working papers
Please find below working papers of our group. Currently, we list 58 working papers.
In the list are only not published papers present. If you look for a preprint of an already published paper you must look in the "Published papers" section.
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A Sequence-to-Function Map for Ribozyme-catalyzed Metabolisms
Alexander Ullrich and Christoph Flamm
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Status: Accepted
European Conference on Artificial Life 2009, LNCS/LNAI 5777/5778 2010 (in press)
Abstract
We introduce a novel genotype-phenotype mapping based on
the relation between RNA sequence and its secondary structure for the
use in evolutionary studies. Various extensive studies concerning RNA
folding in the context of neutral theory yielded insights about properties
of the structure space and the mapping itself. We intend to get a
better understanding of some of these properties and especially of the
evolution of RNA-molecules as well as their effect on the evolution of the
entire molecular system. We investigate the constitution of the neutral
network and compare our mapping with other artificial approaches using
cellular automatons, random boolean networks and others also based on
RNA folding. We yield the highest extent, connectivity and evolvability
of the underlying neutral network. Further, we successfully apply the
mapping in an existing model for the evolution of a ribozyme-catalyzed
metabolism.