Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
A Sequence-to-Function Map for Ribozyme-catalyzed Metabolisms
Alexander Ullrich and Christoph Flamm
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PREPRINT 10-017: [ PDF ]
Status: Accepted
European Conference on Artificial Life 2009, LNCS/LNAI 5777/5778 2010 (in press)
Abstract
We introduce a novel genotype-phenotype mapping based on
the relation between RNA sequence and its secondary structure for the
use in evolutionary studies. Various extensive studies concerning RNA
folding in the context of neutral theory yielded insights about properties
of the structure space and the mapping itself. We intend to get a
better understanding of some of these properties and especially of the
evolution of RNA-molecules as well as their effect on the evolution of the
entire molecular system. We investigate the constitution of the neutral
network and compare our mapping with other artificial approaches using
cellular automatons, random boolean networks and others also based on
RNA folding. We yield the highest extent, connectivity and evolvability
of the underlying neutral network. Further, we successfully apply the
mapping in an existing model for the evolution of a ribozyme-catalyzed
metabolism.