Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Evolution of the let-7 microRNA Family
Jana Hertel, Sebastian Bartschat, Axel Wintsche, Christian Otto, The Students of the Bioinformatics Computer Lab 2011, Peter F Stadler
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Status: Published
RNA Biology 9: 231-241 (2012)
Abstract
The increase of bodyplan complexity in early bilaterian evolution is intimately linked with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene
expression involved in cell fate choices and transitions between pluripotency and differentiation. One of the two
known microRNAs whose origins date back before the bilaterian ancestor is mir-100. In bilateria it appears stably
associated in polycistronic transcripts with let-7 and mir-125, two key regulators of development. In vertebrates, these three microRNA families have expanded to form a complex system of developmental regulators. In this contribution we disentangle the evolutionary history of the let-7 locus, which was restructured independently in nematodes, platyhelminths and deuterostomes. The foundation of a second let-7 locus in the common ancestor of vertebrates and urochordates predates the vertebrate-specific genome duplications, which then caused a rapid expansion of let-7 family.
Keywords
micro RNA, let-7, mir-100, mir-125, miRNA evolution