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BIOINF 11-022: Evolution of the let-7 microRNA Family
Jana Hertel, Sebastian Bartschat, Axel Wintsche, Christian Otto, The Students of the Bioinformatics Computer Lab 2011, Peter F Stadler
Extended Cluster Summary
Extendend tables summarizing the deuterostomian let-7 associated cluster can be downloaded here. Therein, miRBase names were noted when this microRNA is already annotated.Genomic Location
- GFF file containing all collected let-7 associated microRNAs among Deuterostomia [gff]
- Genome versions we used during our analysis [list]
Please note that the sequences ssc-C-mir-125 and ggo-D-mir-100 are solely experimentally derived and hence won't appear in the gff file.
- GFF file containing all mirbase-derived let-7 associated microRNAs among Protostomia and Cnidaria [gff]
- Genome versions of protostomes we used during out analysis [list]
MicroRNA family Alignments
Alignments of let-7, mir-100, and mir-125 families in Stockholm format can be downloaded here.Deuterostomia: | ||||
---|---|---|---|---|
Cluster A | A-mir-100.stk | A-let-7.stk | A-mir-125.stk | |
Cluster A(Tel) | A-Tel-let-7.stk | A-Tel-mir-125.stk | ||
Cluster C | C-mir-100.stk | C-let-7.stk | C-mir-125.stk | |
Cluster D | D-mir-100.stk | D-let-7.stk | D-mir-125.stk | |
Cluster E | E-let-7-1.stk | E-let-7-2.stk | E-let-7-3.stk | |
Cluster F | F-let-7-1.stk | F-let-7-2.stk | ||
Cluster G | G-let-7-1.stk | G-let-7-2.stk | ||
Cluster H | H-let-7-1.stk | H-let-7-2.stk | ||
Cluster I | I-let-7.stk | |||
Cluster J | J-let-7.stk | |||
Cluster K | K-let-7.stk | |||
Cluster L | L-let-7.stk | |||
Protostomia: | ||||
mixed Cluster | mir-100.stk | let-7.stk | mir-125.stk | |
lin-4 | lin4.stk |
Covariance Models
(Sub)family-wide covariance models were used for structure and sequence-based homology searches for the deuterosome microRNAs of the let-7, mir-100, and mir-125 families.Cluster A | A-mir-100.cm | A-let-7.cm | A-mir-125.cm | |
Cluster A(Tel) | A-Tel-let-7.cm | A-Tel-mir-125.cm | ||
Cluster C | C-mir-100.cm | C-let-7.cm | C-mir-125.cm | |
Cluster D | D-mir-100.cm | D-let-7.cm | D-mir-125.cm | |
Cluster E | E-let-7-1.cm | E-let-7-2.cm | E-let-7-3.cm | |
Cluster F | F-let-7-1.cm | F-let-7-2.cm | ||
Cluster G | G-let-7-1.cm | G-let-7-2.cm | ||
Cluster H | H-let-7-1.cm | H-let-7-2.cm | ||
Cluster I | I-let-7.cm | |||
Cluster J | J-let-7.cm | |||
Cluster K | K-let-7.cm | |||
Cluster L | L-let-7.cm |