Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:
webmaster@bioinf.uni-leipzig.de
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:webmaster@bioinf.uni-leipzig.de
©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Sequence assembly
Karsten Scheibye-Alsing, Steve Hoffmann, Annett M. Frankel, Peter Jensen, Peter F. Stadler, Yuan Mang, Niels Tommerup, Mike J Gilchrist, Ann-Britt N. Hillig, Susanna Cirera, Claus B Jørgensen, Merete Fredholm, and Jan Gorodkin.
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Status: Published
Comp. Biol. Chem., 33:121–136, 2009.
Abstract
Despite the rapidly increasing number of sequenced and re-sequenced genomes, many issues regarding the computational
assembly of large-scale sequencing data have remain unresolved. Computational assembly is crucial in large genome
projects as well for the evolving high-throughput technologies and plays an important role in processing the information generated by these methods. Here, we provide a comprehensive overview of the current publicly available sequence assembly programs. We describe the basic principles of computational assembly along with the main concerns, such as repetitive sequences in genomic DNA, highly expressed genes and alternative transcripts in EST sequences. We summarize existing comparisons of different assemblers and provide a detailed descriptions and directions for download of assembly programs at: http://genome.ku.dk/resources/assembly/methods.html.