Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
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) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication
Jörg Lehmann, Carina Eisenhardt, Peter F. Stadler, Veiko Krauss
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Status: Published
BMC Evol. Biol. 10: 156 (2010)
Abstract
<b>Background</b>
Positions of spliceosomal introns are often conserved between remotely related genes.
Introns that reside in non-conserved positions are either novel or remnants of frequent
losses of introns in some evolutionary lineages. A recent gain of such introns is
difficult to prove. However, introns verified as novel are needed to evaluate
contemporary processes of intron gain.<br>
<b>Results</b>
We identified 25 unambiguous cases of novel intron positions in 31 Drosophila genes
that exhibit near intron pairs (NIPs). Here, a NIP consists of an ancient and a novel
intron position that are separated by less than 32 nt. Within a single gene, such
closely-spaced introns are very unlikely to have coexisted. In most cases, therefore,
the ancient intron position must have disappeared in favour of the novel one. A survey
for NIPs among 12 Drosophila genomes identifies intron sliding (migration) as one of
the more frequent causes of novel intron positions. Other novel introns seem to have
been gained by regional tandem duplications of coding sequences containing a proto-splice
site.<br>
<b>Conclusions</b>
Recent intron gains sometimes appear to have arisen by duplication of exonic
sequences and subsequent intronization of one of the copies. Intron migration and
exon duplication together may account for a significant amount of novel intron
positions in conserved coding sequences.
Keywords
Introns, Near-Intron-Positions, Drosophila, Intron Sliding, Tandem Duplication