Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
MITOS: Improved <i>de novo</i> Metazoan Mitochondrial Genome Annotation
Matthias Bernt, Alexander Donath, Frank Jühling, Fabian Externbrink, Catherine Florentz, Guido Fritzsch, Joern Pütz, Martin Middendorf, and Peter F. Stadler
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Status: Published
Mol. Phylog. Evol. 69:313–319 (2013)
Abstract
About 2000 completely sequenced mitochondrial genomes are available from the
NCBI RefSeq data base together with manually curated annotations of their
protein-coding genes, rRNAs, and tRNAs. This annotation information, which
has accumulated over two decades, has been obtained with a diverse set of
computational tools and annotation strategies. Despite all efforts of manual
curation it is still plagued by misassignments of reading directions, erroneous
gene names, and missing as well as false positive annotations in particular
for the RNA genes.
Taken together, this causes substantial problems for fully automatic pipelines
that aim to use these data comprehensively for studies of animal phylogenetics
and the molecular evolution of mitogenomes. The MITOS pipeline is designed
to compute a consistent <i>de novo</i> annotation of the mitogenomic sequences. We
show that the results of MITOS match RefSeq and MitoZoa in terms of annotation
coverage and quality. At the same time we avoid biases, inconsistencies
of nomenclature, and typos originating from manual curation strategies. The
MITOS pipeline is accessible online at http://mitos.bioinf.uni-leipzig.de.
Keywords
Metazoa, Mitochondria, Genome, Annotation, Server
Note
http://mitos.bioinf.uni-leipzig.de/