Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
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) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Evolution of 7SK RNA and Its Protein Partners in Metazoa
Manja Marz*, Alexander Donath*, Nina Verstraete, Van Trung Nguyen, Peter F. Stadler, Olivier Bensaude
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Status: Published
Mol Biol Evol. 2009 Dec;26(12):2821-30.
Abstract
7SK RNA is a key player in the regulation of polymerase II
transcription. 7SK RNA was considered as a highly conserved vertebrate
innovation. The discovery of poorly conserved homologs in several insects
and lophotrochozoans, however, implies a much earlier evolutionary
origin. The mechanism of 7SK function requires interaction with the
proteins HEXIM and LARP7. Here, we present a comprehensive computational
analysis of these two proteins in metazoa, and we extend the collection
of 7SK RNAs by several additional candidates. In particular we describe
7SK homologs in \emph{Caenorhabditis} species. Furthermore, we derive an
improved secondary structure model of 7SK RNA, which shows that the
structure is quite well-conserved across animal phyla despite the extreme
divergence at sequence level.
Keywords
Hexim, 7SK RNA, LARP7, MePCE, Polymerase III transcription, non-coding RNA, Secondary Structure