Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
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) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Mutate Now, Die Later
Andreea Munteanu, Peter F. Stadler
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Status: Published
J Theor Biol. 260:412-421 (2009)
Abstract
We analyze here the evolutionary consequences of selection with delay in a
population genetics context. In the classical works on evolutionary
dynamics, an individual produces off-springs in direct proportion to its
fitness, a process in which mutations may occur. In the present scenario
of delayed selection, individuals that acquire deleterious mutations can
still reproduce unharmed for several generations. During this time delay,
the damage passed on to off-springs can potentially be repaired by
subsequent compensatory mutations. In the absence of such a repair, the
individual becomes sterile. Here we study the population-genetic effects of
such a time delay by means of both numerical simulations and theoretical
modeling. The results show that delayed selection lowers the
error threshold, endangering the survival of the population. Surprisingly,
however, no traces of this delay effect are encountered in the sequence
diversity of the population. These conclusions suggest that delayed
selection is hard to detect in genetic data and thus could be a wide-spread
but rarely detected phenomenon.
Keywords
Evolution, neutral networks, fitness, extinction, telomere \