Publications - Working papers
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Boolean networks with veto functions
Haleh Ebadi, Konstantin Klemm
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Abstract
Boolean networks are discrete dynamical systems for modeling regulation and signaling in living
cells. We investigate a particular class of Boolean functions with inhibiting inputs exerting a veto
(forced zero) on the output. We give analytical expressions for the sensitivity of these functions and
provide evidence for their role in natural systems. In an intracellular signal transduction network
[Helikar et al., PNAS (2008)], the functions with veto are over-represented by a factor exceeding
the over-representation of threshold functions and canalyzing functions in the same system. In
Boolean networks for control of the yeast cell cycle [Fangting Li et al., PNAS (2004), Davidich et
al., PLoS One (2009)], none or minimal changes to the wiring diagrams are necessary to formulate
their dynamics in terms of the veto functions introduced here.