Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
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) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Analyzing Histone Modifications Using Tiled Binned Clustering and 3D Scatter Plots
Dirk Zeckzer, and Daniel Wiegreffe, and Lydia Müller,
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Status: Published
Journal of WSCG 26
Abstract
A major goal in epigenetics is understanding how cells differentiate into different cell types. Besides the increaseof individual data sets, the amount of replicated experiments generating a tremendous amount of data is everincreasing. While biologists primarily analyze their data on the highest level using statistical correlations or on thelowest level analyzing nucleotide sequences, determining the fate of histone modifications during cell specificationnecessitates improved analysis capabilities on one or more intermediate levels. For this type of analysis, it proved tobe very useful to use tiled binned scatter plot matrices showing binary relationships or to use tiled binned 3D scatterplots showing ternary relationships. Quarternary or general n-ary relationships are not easily analyzable usingvisualization techniques like scatter plots, only. Therefore, we augmented existing clustering methods with thetiling and binning idea enabling the analysis of n-ary relationships. Analyzing the changes of histone modificationscomparing two cell lines using tiled binned clustering, we found new, unknown relations in the data.