Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Dicer-Processed Small RNAs: Rules and Exceptions
David Langenberger, M. Volkan C, Steve Hoffmann, Peter F. Stadler
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Status: Published
J.Exp.Zool.B Mol.Dev.Evol. 320: 35-46 (2012)
Abstract
Canonical microRNAs are excised from their hairpin-shaped precursors by Dicer. In order to find possible exceptions
to this rule and to identify additional substrates for Dicer processing we re-evaluate the small RNA sequencing data
of the Dicer knockdown experiment in MCF-7 cells originally published by Friedl¨ander et al. [Nucleic Acids Res. 40:
37-52 (2012)]. While the well-known non-Dicer mir-451 is not sufficiently expressed in these experiments, there are
several additional Dicer-independent microRNAs, among them the important tumor supressor mir-663a. We recover
previously described examples of non-miRNA Dicer substrates such as tRNA-Gln and several snoRNAs. Interestingly,
sdRNAs derived from box C/D snoRNAs are Dicer-independent, while those derived from box H/ACA snoRNAs are
often Dicer dependent. Several pol-III transcripts, in particular the vault RNAs and the great ape specific snaRs are
processed by Dicer, while the small RNAs originating from Y RNAs seem to be Dicer independent.
Keywords
sdRNAs, snoRNAs, Y RNAs, vault RNAs, snaRs