Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
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webmaster@bioinf.uni-leipzig.de
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:webmaster@bioinf.uni-leipzig.de
©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Identification and Classification of Small RNAs in Transcriptome Sequence Data
D. Langenberger, C.I. Bermudez-Santana, P.F. Stadler, S. Hoffmann
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Status: Published
Pac Symp Biocomput. 2010:80-7
Abstract
Current methods for high throughput sequencing (HTS) for the first time offer the opportunity to investigate the
entire transcriptome in an essentially unbiased way. In many species, small non-coding RNAs with specific secondary
structures constitute a significant part of the transcriptome. Some of these RNA classes, in particular microRNAs
and snoRNAs, undergo maturation processes that lead to the production of shorter RNAs. After mapping the
sequences to the reference genome specific patterns of short reads can be observed. These read patterns seem to
reflect the processing and thus are specific for the RNA transcripts of which they are derived from. We explore here
the potential of short read sequence data in the classification and identification of non-coding RNAs.
Keywords
High throughput sequencing; read patterns; small RNA processing; small RNA classification; machine learning