Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Evolution of vault RNAs
Peter F. Stadler, Julian J.-L. Chen, Jörg Hackermüller, Steve Hoffmann, Friedemann Horn, Phillip Khaitovich, Antje Kretzschmar, Axel Mosig, Sonja J. Prohaska, Xiaodong Qi, Katharina Schutt, Kerstin Ullmann
Download
Status: Published
Mol Biol Evol. 2009; 26(9):1975-91
Abstract
Vault RNAs (vRNAs) are small, about 100nt long, poly-III transcripts
contained in the vault particles of eukaryotic cells. Presumably due to
their enigmatic function they have received little attention compared to
other ncRNA families. Here we report on a systematic study of this rapidly
evolving class of ncRNAs in Deuterostomia, providing a comprehensive
collection of computationally predicted vRNA genes. Previously known vRNAs
are located at a conserved location linked to the protocadherin gene
cluster, an association that is conserved throughout gnathostomes. Lineage
specific expansion to small vRNA gene clusters are frequently observed at
this locus. Expression of several paralogous vRNA genes, most but not all
located at the canonical syntenically conserved locus, was verified by
RT-PCR in both zebrafish and medaka. Homology search furthermore
identifies an additional vRNA gene in eutheria that was misclassified as a
microRNA. Lineage specific loss of one of the two loci in several eutherian
lineages supports the annotation as novel vRNA. The comparative analysis of
the promoter structure shows substantial differences between the two
eutherian vRNA types, explaining their differential expression patterns in
human cancer cell lines.