Publications - Published papers
Please find below publications of our group. Currently, we list 565 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:
) is restricted to our local network and chosen collaborators.
If you have problems accessing electronic information, please let us know:©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.
Interleukin-6–dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer
D. Löffler, K. Brocke-Heidrich, G. Pfeifer, C. Stocsits, J. Hackermüller, A. Kretzschmar, R. Burger, M. Gramatzki, C. Blumert, K. Bauer, H. Cvijic, P. F. Stadler, and F. Horn
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Status: Published
Blood
Abstract
Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of
many malignancies and essential for IL-6-dependent survival and growth of multiple myeloma
cells. Here, we demonstrate that the gene encoding oncogenic microRNA-21 (miR-21) is
controlled by an upstream enhancer containing two Stat3 binding sites strictly conserved since
the first observed evolutionary appearance of miR-21 and Stat3. MiR-21 induction by IL-6 was
strictly Stat3-dependent. Ectopically raising miR-21 expression in myeloma cells in the absence
of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that
miR-21 induction contributes to the oncogenic potential of Stat3.
Note
DOI 10.1182/blood-2007-03-081133