Proteinortho - Orthology detection tool

Proteinortho is a tool to detect orthologous genes within different species. This software can used, redistributed and modified GNU General Public License version 2 or later.


The project is now made available via GitLab.


Manual (

Current version

Latest Proteinortho6 version (GitLab)


If you use Proteinortho in your work you might want to cite: Lechner et al (2011). Proteinortho: Detection of (Co-)Orthologs in Large-Scale Analysis. BMC Bioinformatics 2011 Apr 28;12(1):124.

Old versions

View Proteinortho6 / PoFF manual 2019-02-05: Proteinortho V6.0b - Source code View Proteinortho5 / PoFF manual 2017-09-22: Proteinortho V5.16b - Source code with precompiled binaries (Linux/x64) / Proteinortho V5.16b - Source code only 2017-04-18: Proteinortho V5.16 - Source code with precompiled binaries (Linux/x64) / Proteinortho V5.16 - Source code only Past releases can be found here