Downloads¶

Latest version¶

You can download the latest version of metilene here. Download the user guide here and the publication is here.

Some bug fixes and modernisations courtesy of Konstantin Riege:
output truncated and unpredictable as of GCC version 12+ due to illegal stack copy operation
scripts shebang containing absolute path
pthreads used as linker option only and not as compiler option, old C standard 99
potential overflow when pretty printing date and time
unsafe macro expansions
tab/space mix of indentations (cosmetic)

New option added to select Benjamini-Hochberg (FDR) as method for multiple testing correction of p-values. New option added to set maximum segment length in case of memory issues. Assignment of samples to groups is now done via prefix instead of substring matches and incorporation of an additional check to prevent samples to be assigned to both groups. Alternative random number generator PCG (http://www.pcg-random.org) instead of stdlib's rand() added to provide reproducible results across different platforms that can be enabled with the additional compiler flag "-DPCGRNG". Precision of p-values and adjusted p-values in output was increased from 2 to 5.

Calculation of mean difference per DMR in DMC modus. Concordant with other modi it is group1 mean - group2 mean.

(including input/output wrappers)
Versioning updated
Predefined cutoff for -X and -Y options corrected (set to 0.8 as specified in the manual)
Seed for random generator initialized with a specific number