M14008. Recombinant avian retrovirus MH2E21 LOCUS AC2E21CG 2630 bp ss-RNA linear VRL 27-APR-1993 DEFINITION Recombinant avian retrovirus MH2E21, complete genome. ACCESSION M14008 VERSION M14008.1 GI:209645 KEYWORDS c-myc proto-oncogene; complete genome; long terminal repeat (LTR); myc gene. SOURCE Avian carcinoma virus ORGANISM Avian carcinoma virus Viruses; Retroid viruses; Retroviridae; Alpharetrovirus. REFERENCE 1 (bases 1 to 2630) AUTHORS Patschinsky,T., Jansen,H.W., Blocker,H., Frank,R. and Bister,K. TITLE Structure and transforming function of transduced mutant alleles of the chicken c-myc gene JOURNAL J. Virol. 59 (2), 341-353 (1986) MEDLINE 86281833 PUBMED 3016301 COMMENT Original source text: Recombinant avian carcinoma virus MH2E21 (derived from a mil-deletion mutant of MH2, see comment), integrated proviral DNA, clone pMH2E21-E. Computer-readable sequence of [1] kindly provided by K.Bister (26-JAN-1987). The sequence presented below represents the complete proviral genome including two complete LTRs derived from figure 3 in [1]. The terminal inverted repeats 5' 'aatg' and 'catt' 3' (positions 1-4 and 2627-2630 respectively) may not be completely present in the integrated proviral DNA. The MH2E21 myc protein differs from chicken c-myc and MH2 virus v-myc. [1] constucted various mutants of MH2E21 that expressed variant myc proteins. [1] describes the construction and isolation of the MH2E21 retrovirus. The MH2E21 virus appears to be a recombinant between ring-necked pheasant virus and a deletion mutant of MH2 that was constructed in vitro. The MH2E21 virus lacks gag, pol and env genes, and thus needs a helper virus to reproduce. FEATURES Location/Qualifiers source 1..2630 /organism="Avian carcinoma virus" /mol_type="genomic RNA" /db_xref="taxon:11958" LTR 1..357 /note="5' LTR" repeat_region 257..277 /note="5' R region" CDS 655..1926 /note="v-myc (59/61 kDa) protein" /codon_start=1 /protein_id="AAA42389.1" /db_xref="GI:209646" /translation="MEAVIKAAAAAMPLSVSLPSKNYDYDYDSVQPYFYFEEEEENFY LAAQQRSSELQPPAPSEDIWKKFELLPAPPLSPSCRSNLAAASCFPSTADQLEMVTEL LGGDMVNQSSICDPDDESFVKSIIIRDCMWSGFSAAAKLEKVVSEKLATYKASRREGG PAAASRPGPPPSGPPPPPAGPAASAGLYLHDLGAAAAGCIGSSVVFPCPLGRRGPPGA GPAALLGVDAPPTAGGGSEEEQEEDEEIDVVTLAEANESESSTESSTEASEEHCKPHH SPLVLERCHVNIHQHNYAAPPSTKVEYPAAKRLKLDSGRVLKQVSNNRKCSSPRTSDS EVNDKRRTHNVLERQRRNELKLSFFALRDQIPEVANNEKAPKVVILKRATEYVLSIQS DEHRLIAEKEQLRRRREQLKHKLEQLRNSRA" LTR 2274..2630 /note="3' LTR" repeat_region 2530..2550 /note="3' R region" ORIGIN 203 bp upstream of EcoRI site. 1 aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg cttatgtaac gatgagttag 61 caacatgcct tataaggaaa gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 121 tatgatcgtg gtatgatcgt ggtatgatcg tgccttatta ggaaggcaac agacgggtct 181 aacacggatt ggacgaacca ctgaattccg cattgcagag atattgtatt taagtgccta 241 gctcgataca ataaacgcca tttgaccatt caccacattg gtgtgcacct gggttgatgg 301 ccggaccgtt gattccctga cgactacgag cacatgcatg aagcagaagg cttcatttgg 361 tgaccccgac gtgatcgtta gggaatagtg gtcggccaca ggcggcgtgg cgatcctgtc 421 ctcatccgtc tcgcttattc ggggagcgga cgatgaccct agtagagggg gctgcggctt 481 aggagggcag aagctgagtg acgtcggagg gagctccacg gccgggggcc aagataccct 541 accgagaact cagagagtcg ttggaagacg ggaagaaagc ccgacgactg agcggtccac 601 cccaggcgtg attccggttg ctctgcgtga ttccggtcgc ccggtgaatc aagcatggaa 661 gccgtcataa aggcagcagc cgccgcgatg ccgctcagcg tcagcctccc cagcaagaac 721 tacgattacg actacgactc ggtgcagccc tacttctact tcgaggagga ggaggagaac 781 ttctacctgg cggcgcagca gcggagcagc gagctgcagc ctccagcccc gtccgaggac 841 atctggaaga agtttgagct cctgcccgcg ccgcccctct cgcccagctg ccgctccaac 901 ctggccgccg cctcctgctt cccttccacc gccgaccagc tggagatggt gacggagctg 961 ctcggggggg acatggtcaa ccagagctcc atctgcgacc cggacgacga atccttcgtc 1021 aaatccatca tcatccggga ctgcatgtgg agcggcttct ccgccgccgc caagctggag 1081 aaggtggtgt cggagaagct cgccacctac aaagcctccc gccgggaggg gggccccgcc 1141 gccgcctccc gacccggccc gccgccctcg gggccgccgc ctcctcccgc cggccccgcc 1201 gcctcggccg gcctctacct gcacgacctg ggagccgcgg ccgccggctg catcggctcc 1261 tcggtggtct tcccctgccc gctcggcagg cgcggcccgc ccggcgccgg ccccgcggct 1321 ctgctggggg tcgacgcgcc gcccacggcc ggcggcggct cggaggaaga acaagaagaa 1381 gatgaggaaa tcgatgtcgt tacattagct gaagcgaacg agtctgaatc cagcacagag 1441 tccagcacag aagcatcaga ggagcactgt aagccccacc acagtccgct ggtcctcgag 1501 cggtgtcacg tcaacatcca ccaacacaac tacgctgctc ctccctccac caaggtggaa 1561 tacccagccg ccaagaggct aaagttggac agtggcaggg tcctcaaaca ggtcagcaac 1621 aaccgaaaat gctccagtcc ccgcacgtca gactcagagg tgaacgacaa gaggcgaacg 1681 cacaacgtct tggagcgcca gcgaaggaat gagctgaagc tgagcttctt tgccctgcgg 1741 gaccagatac ccgaggtggc caacaacgag aaggcgccca aggttgtcat cctgaaaaga 1801 gccacggagt acgttctgtc tatccaatcg gacgagcaca gactgatcgc agagaaagag 1861 cagttgaggc ggaggagaga acagttgaaa cacaaacttg agcagctaag gaactctcgt 1921 gcataggaac tcttggacat cacttagaat accccaaact agactccgtg tgatagctgg 1981 ttggatcgtt aatcggacgg ctggcacacg gaatgtagga ggtcgctgag taagtacgaa 2041 caaaatttac gttgtaataa ggtgaggctt gacctacaat tgttcaaata atgcttctgt 2101 agaaatgttt agcattaggc atcttgcgct gctccgcgat gtacgggtca ggtataatgt 2161 gcagtttgac tgaggggacc atgatatgta taggcgaaag gcggggcttc ggttgtacgc 2221 ggttaggagt cccctcagga tatagtagtt tcgcttttgc atagggaggg ggaaatgtag 2281 tcttatgcaa tactcttgta gtcttgcaac atgcttatgt aacgatgagt tagcaacatg 2341 ccttataagg aaagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtatgatc 2401 gtggtatgat cgtggtatga tcgtgcctta ttaggaaggc aacagacggg tctaacacgg 2461 attggacgaa ccactgaatt ccgcattgca gagatattgt atttaagtgc ctagctcgat 2521 acaataaacg ccatttgacc attcaccaca ttggtgtgca cctgggttga tggccggacc 2581 gttgattccc tgacgactac gagcacatgc atgaagcaga aggcttcatt //