RID=1097221795-25427-187069014845.BLASTQ1,

BLASTP 2.2.9 [May-01-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402.
RID: 1097221795-25427-187069014845.BLASTQ1
Query= (330 letters)
Database: PDB protein database 18,695 sequences; 4,163,319 total letters
If you have any problems or questions with the results of this search
please refer to the BLAST FAQs
Results of PSI-Blast iteration 1 Taxonomy reports
Distribution of 17 Blast Hits on the Query Sequence


Legend:
 - means that the alignment score was below the threshold on the previous iteration 
 - means that the alignment was checked on the previous iteration 


Hit list size 
Sequences with E-value BETTER than threshold
Related Structures
                                                                     Score    E
Sequences producing significant alignments:                          (bits) Value




Sequences with E-value WORSE than threshold


 gi|33357073|pdb|1IZ3|A  Chain A, Dimeric Structure Of Fih (Factor...    31   0.22  

 gi|27065049|pdb|1H2N|A  Chain A, Factor Inhibiting Hif-1 Alpha >g...    31   0.25  

 gi|27065812|pdb|1MZF|A  Chain A, Human Factor Inhibiting Hif (Fih...    31   0.25  

 gi|42543131|pdb|1NRF|A  Chain A, C-Terminal Domain Of The Bacillu...    30   0.51  

 gi|27574087|pdb|1N63|E  Chain E, Crystal Structure Of The Cu,Mo-C...    29   1.1   

 gi|51247136|pdb|1OKZ|A  Chain A, Structure Of Human Pdk1 Kinase D...    28   2.6   

 gi|47169288|pdb|1UU9|A  Chain A, Structure Of Human Pdk1 Kinase D...    28   2.8   

 gi|47169307|pdb|1UVR|A  Chain A, Structure Of Human Pdk1 Kinase D...    28   2.9   

 gi|49259007|pdb|1SIW|B  Chain B, Crystal Structure Of The Apomoly...    27   6.0   

 gi|6730157|pdb|1C5G|A  Chain A, Plasminogen Activator Inhibitor-1       27   6.3   

 gi|10120510|pdb|1DVM|D  Chain D, Active Form Of Human Pai-1 >gi|1...    27   6.6   

 gi|33357654|pdb|1OC0|A  Chain A, Plasminogen Activator Inhibitor-...    27   6.6   

 gi|6573637|pdb|1DB2|B  Chain B, Crystal Structure Of Native Plasm...    27   6.7   

 gi|21466093|pdb|1LJ5|A  Chain A, 1.8a Resolution Structure Of Lat...    27   6.8   

 gi|4699714|pdb|1A7C|A  Chain A, Human Plasminogen Activator Inhib...    26   7.4   

 gi|4699815|pdb|9PAI|A  Chain A, Cleaved Substrate Variant Of Plas...    26   7.4   

 gi|50513707|pdb|1T5L|B  Chain B, Crystal Structure Of The Dna Rep...    26   8.7   


Alignments








>gi|33357073|pdb|1IZ3|A   Chain A, Dimeric Structure Of Fih (Factor Inhibiting Hif)
          Length = 349

 Score = 31.2 bits (69), Expect = 0.22
 Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 15/123 (12%)

Query: 113 WIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEKTWKLAKNENVSN 172
           WI K + +      TS+  ++     G    AH+D   N   QI+G K   L        
Sbjct: 169 WINKQQGKRGWGQLTSNLLLI--GXEGNVTPAHYDEQQNFFAQIKGYKRCILFP------ 220

Query: 173 PMQHYDLSEAP-YYPDDLQSYWKGDPPK-EDLPDAEIVN-----LTPGTMLYLPRGLWHS 225
           P Q   L   P ++P D QS    D P  E  P+ + V      + PG +LY+P   WH 
Sbjct: 221 PDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPXYWWHH 280

Query: 226 TKS 228
            +S
Sbjct: 281 IES 283



>gi|27065049|pdb|1H2N|A   Chain A, Factor Inhibiting Hif-1 Alpha
 gi|27065046|pdb|1H2M|A   Chain A, Factor Inhibiting Hif-1 Alpha In Complex With Hif-1 Alpha
           Fragment Peptide
 gi|27065042|pdb|1H2L|A   Chain A, Factor Inhibiting Hif-1 Alpha In Complex With Hif-1 Alpha
           Fragment Peptide
 gi|27065036|pdb|1H2K|A   Chain A, Factor Inhibiting Hif-1 Alpha In Complex With Hif-1 Alpha
           Fragment Peptide
          Length = 349

 Score = 31.2 bits (69), Expect = 0.25
 Identities = 35/123 (28%), Positives = 50/123 (40%), Gaps = 15/123 (12%)

Query: 113 WIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEKTWKLAKNENVSN 172
           WI K +   +   G  +  ++     G    AH+D   N   QI+G K   L        
Sbjct: 169 WINKQQG--KRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFP------ 220

Query: 173 PMQHYDLSEAP-YYPDDLQSYWKGDPPK-EDLPDAEIVN-----LTPGTMLYLPRGLWHS 225
           P Q   L   P ++P D QS    D P  E  P+ + V      + PG +LY+P   WH 
Sbjct: 221 PDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHH 280

Query: 226 TKS 228
            +S
Sbjct: 281 IES 283



>gi|27065812|pdb|1MZF|A   Chain A, Human Factor Inhibiting Hif (Fih1) In Complex With 2-
           Oxoglutarate
 gi|27065810|pdb|1MZE|A   Chain A, Human Factor Inhibiting Hif (Fih1)
          Length = 351

 Score = 31.2 bits (69), Expect = 0.25
 Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 15/123 (12%)

Query: 113 WIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEKTWKLAKNENVSN 172
           WI K + +      TS+  ++     G    AH+D   N   QI+G K   L        
Sbjct: 171 WINKQQGKRGWGQLTSNLLLI--GMEGNVTPAHYDEQQNFFAQIKGYKRCILFP------ 222

Query: 173 PMQHYDLSEAP-YYPDDLQSYWKGDPPK-EDLPDAEIVN-----LTPGTMLYLPRGLWHS 225
           P Q   L   P ++P D QS    D P  E  P+ + V      + PG +LY+P   WH 
Sbjct: 223 PDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHH 282

Query: 226 TKS 228
            +S
Sbjct: 283 IES 285



>gi|42543131|pdb|1NRF|A   Chain A, C-Terminal Domain Of The Bacillus Licheniformis Blar
           Penicillin-Receptor
          Length = 262

 Score = 30.0 bits (66), Expect = 0.51
 Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 3/81 (3%)

Query: 83  VSPAEALEWYEKGAALEFDFTDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGF 142
           +SP E +   +K    EFDF    I  V+  I   ++  R+ +G +  +++    + G F
Sbjct: 156 ISPLEQVNILKKFYDNEFDFKQSNIETVKDSIRLEESNGRVLSGKTGTSVINGELHAGWF 215

Query: 143 KAHFDAYTNLIF---QIQGEK 160
             + +   N  F    IQGEK
Sbjct: 216 IGYVETADNTFFFAVHIQGEK 236



>gi|27574087|pdb|1N63|E   Chain E, Crystal Structure Of The Cu,Mo-Co Dehydrogenase (Codh);
           Carbon Monoxide Reduced State
 gi|27574084|pdb|1N63|B   Chain B, Crystal Structure Of The Cu,Mo-Co Dehydrogenase (Codh);
           Carbon Monoxide Reduced State
 gi|27574081|pdb|1N62|E   Chain E, Crystal Structure Of The Mo,Cu-Co Dehydrogenase (Codh), N-
           Butylisocyanide-Bound State
 gi|27574078|pdb|1N62|B   Chain B, Crystal Structure Of The Mo,Cu-Co Dehydrogenase (Codh), N-
           Butylisocyanide-Bound State
 gi|27574075|pdb|1N61|E   Chain E, Crystal Structure Of The Cu,Mo-Co Dehydrogenase (Codh);
           Dithionite Reduced State
 gi|27574072|pdb|1N61|B   Chain B, Crystal Structure Of The Cu,Mo-Co Dehydrogenase (Codh);
           Dithionite Reduced State
 gi|27574069|pdb|1N60|E   Chain E, Crystal Structure Of The Cu,Mo-Co Dehydrogenase (Codh);
           Cyanide-Inactivated Form
 gi|27574066|pdb|1N60|B   Chain B, Crystal Structure Of The Cu,Mo-Co Dehydrogenase (Codh);
           Cyanide-Inactivated Form
 gi|27574059|pdb|1N5W|E   Chain E, Crystal Structure Of The Cu,Mo-Co Dehydrogenase (Codh);
           Oxidized Form
 gi|27574056|pdb|1N5W|B   Chain B, Crystal Structure Of The Cu,Mo-Co Dehydrogenase (Codh);
           Oxidized Form
          Length = 809

 Score = 28.9 bits (63), Expect = 1.1
 Identities = 14/48 (29%), Positives = 25/48 (52%), Gaps = 4/48 (8%)

Query: 61  NPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDFTDLFIP 108
           NP+++ G        G+T+ F V+  + + + E+G  L   F D F+P
Sbjct: 691 NPMIIEGQV----HGGLTEAFAVAMGQEIRYDEQGNVLGASFMDFFLP 734



>gi|51247136|pdb|1OKZ|A   Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With
           Ucn-01
 gi|51247135|pdb|1OKY|A   Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With
           Staurosporine
 gi|47169287|pdb|1UU8|A   Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With
           Bim-1
 gi|47169286|pdb|1UU7|A   Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With
           Bim-2
 gi|47169285|pdb|1UU3|A   Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With
           Ly333531
          Length = 310

 Score = 27.7 bits (60), Expect = 2.6
 Identities = 11/26 (42%), Positives = 17/26 (65%)

Query: 92  YEKGAALEFDFTDLFIPQVRRWIEKL 117
           ++K   LE+DF + F P+ R  +EKL
Sbjct: 241 FQKIIKLEYDFPEKFFPKARDLVEKL 266



>gi|47169288|pdb|1UU9|A   Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With
           Bim-3
          Length = 286

 Score = 27.7 bits (60), Expect = 2.8
 Identities = 11/26 (42%), Positives = 17/26 (65%)

Query: 92  YEKGAALEFDFTDLFIPQVRRWIEKL 117
           ++K   LE+DF + F P+ R  +EKL
Sbjct: 220 FQKIIKLEYDFPEKFFPKARDLVEKL 245



>gi|47169307|pdb|1UVR|A   Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With
           Bim-8
 gi|34811348|pdb|1H1W|A   Chain A, High Resolution Crystal Structure Of The Human Pdk1
           Catalytic Domain
          Length = 289

 Score = 27.7 bits (60), Expect = 2.9
 Identities = 11/26 (42%), Positives = 17/26 (65%)

Query: 92  YEKGAALEFDFTDLFIPQVRRWIEKL 117
           ++K   LE+DF + F P+ R  +EKL
Sbjct: 221 FQKIIKLEYDFPEKFFPKARDLVEKL 246



>gi|49259007|pdb|1SIW|B   Chain B, Crystal Structure Of The Apomolybdo-Narghi
 gi|46015401|pdb|1R27|D   Chain D, Crystal Structure Of Nargh Complex
 gi|46015399|pdb|1R27|B   Chain B, Crystal Structure Of Nargh Complex
 gi|37927741|pdb|1Q16|B   Chain B, Crystal Structure Of Nitrate Reductase A, Narghi, From
           Escherichia Coli
          Length = 512

 Score = 26.6 bits (57), Expect = 6.0
 Identities = 24/117 (20%), Positives = 50/117 (42%), Gaps = 9/117 (7%)

Query: 113 WIEKLKAELRLPAGTSSKAI--VYAAKNGGGFKAHFDA----YTNLIFQIQGEKTWKLAK 166
           WI K+  +L+   G  +  +  ++A  +  G   +++     Y NL    +G K+  +A+
Sbjct: 66  WIRKINGKLQPRMGNRAMLLGKIFANPHLPGIDDYYEPFDFDYQNLHTAPEGSKSQPIAR 125

Query: 167 NENVSNPMQHYDLSEAPYYPDDLQSYWK---GDPPKEDLPDAEIVNLTPGTMLYLPR 220
             ++    +   + + P + DDL   +     D   +++  A         M+YLPR
Sbjct: 126 PRSLITGERMAKIEKGPNWEDDLGGEFDKLAKDKNFDNIQKAMYSQFENTFMMYLPR 182



>gi|6730157|pdb|1C5G|A   Chain A, Plasminogen Activator Inhibitor-1
          Length = 402

 Score = 26.6 bits (57), Expect = 6.3
 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 9/71 (12%)

Query: 160 KTWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLP--------DAEIVNLT 211
           +T K    E  +    +YD+ E PY+ D L S +   P ++++P         A++++  
Sbjct: 227 QTNKFNYTEFTTPDGHYYDILELPYHGDTL-SMFIAAPYEKEVPLSALTNILSAQLISHW 285

Query: 212 PGTMLYLPRGL 222
            G M  LPR L
Sbjct: 286 KGNMTRLPRLL 296



>gi|10120510|pdb|1DVM|D   Chain D, Active Form Of Human Pai-1
 gi|10120509|pdb|1DVM|C   Chain C, Active Form Of Human Pai-1
 gi|10120508|pdb|1DVM|B   Chain B, Active Form Of Human Pai-1
 gi|10120507|pdb|1DVM|A   Chain A, Active Form Of Human Pai-1
          Length = 379

 Score = 26.6 bits (57), Expect = 6.6
 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 9/71 (12%)

Query: 160 KTWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLP--------DAEIVNLT 211
           +T K    E  +    +YD+ E PY+ D L S +   P ++++P         A++++  
Sbjct: 204 QTNKFNYTEFTTPDGHYYDILELPYHGDTL-SMFIAAPYEKEVPLSALTNILSAQLISHW 262

Query: 212 PGTMLYLPRGL 222
            G M  LPR L
Sbjct: 263 KGNMTRLPRLL 273



>gi|33357654|pdb|1OC0|A   Chain A, Plasminogen Activator Inhibitor-1 Complex With Somatomedin
           B Domain Of Vitronectin
 gi|6730096|pdb|1B3K|D   Chain D, Plasminogen Activator Inhibitor-1
 gi|6730095|pdb|1B3K|C   Chain C, Plasminogen Activator Inhibitor-1
 gi|6730094|pdb|1B3K|B   Chain B, Plasminogen Activator Inhibitor-1
 gi|6730093|pdb|1B3K|A   Chain A, Plasminogen Activator Inhibitor-1
          Length = 379

 Score = 26.6 bits (57), Expect = 6.6
 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 9/71 (12%)

Query: 160 KTWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLP--------DAEIVNLT 211
           +T K    E  +    +YD+ E PY+ D L S +   P ++++P         A++++  
Sbjct: 204 QTNKFNYTEFTTPDGHYYDILELPYHGDTL-SMFIAAPYEKEVPLSALTNILSAQLISHW 262

Query: 212 PGTMLYLPRGL 222
            G M  LPR L
Sbjct: 263 KGNMTRLPRLL 273



>gi|6573637|pdb|1DB2|B   Chain B, Crystal Structure Of Native Plasminogen Activator
           Inhibitor- 1
 gi|6573636|pdb|1DB2|A   Chain A, Crystal Structure Of Native Plasminogen Activator
           Inhibitor- 1
          Length = 377

 Score = 26.6 bits (57), Expect = 6.7
 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 9/71 (12%)

Query: 160 KTWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLP--------DAEIVNLT 211
           +T K    E  +    +YD+ E PY+ D L S +   P ++++P         A++++  
Sbjct: 202 QTNKFNYTEFTTPDGHYYDILELPYHGDTL-SMFIAAPYEKEVPLSALTNILSAQLISHW 260

Query: 212 PGTMLYLPRGL 222
            G M  LPR L
Sbjct: 261 KGNMTRLPRLL 271



>gi|21466093|pdb|1LJ5|A   Chain A, 1.8a Resolution Structure Of Latent Plasminogen Activator
           Inhibitor-1(Pai-1)
 gi|10835819|pdb|1DVN|A   Chain A, Latent Form Of Plasminogen Activator Inhibitor-1 (Pai-1)
          Length = 379

 Score = 26.6 bits (57), Expect = 6.8
 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 9/71 (12%)

Query: 160 KTWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLP--------DAEIVNLT 211
           +T K    E  +    +YD+ E PY+ D L S +   P ++++P         A++++  
Sbjct: 204 QTNKFNYTEFTTPDGHYYDILELPYHGDTL-SMFIAAPYEKEVPLSALTNILSAQLISHW 262

Query: 212 PGTMLYLPRGL 222
            G M  LPR L
Sbjct: 263 KGNMTRLPRLL 273



>gi|4699714|pdb|1A7C|A   Chain A, Human Plasminogen Activator Inhibitor Type-1 In Complex
           With A Pentapeptide
          Length = 379

 Score = 26.2 bits (56), Expect = 7.4
 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 9/71 (12%)

Query: 160 KTWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLP--------DAEIVNLT 211
           +T K    E  +    +YD+ E PY+ D L S +   P ++++P         A++++  
Sbjct: 204 QTNKFNYTEFTTPDGHYYDILELPYHGDTL-SMFIAAPYEKEVPLSALTNILSAQLISHW 262

Query: 212 PGTMLYLPRGL 222
            G M  LPR L
Sbjct: 263 KGNMTRLPRLL 273



>gi|4699815|pdb|9PAI|A   Chain A, Cleaved Substrate Variant Of Plasminogen Activator
           Inhibitor-1
          Length = 379

 Score = 26.2 bits (56), Expect = 7.4
 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 9/71 (12%)

Query: 160 KTWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLP--------DAEIVNLT 211
           +T K    E  +    +YD+ E PY+ D L S +   P ++++P         A++++  
Sbjct: 204 QTNKFNYTEFTTPDGHYYDILELPYHGDTL-SMFIAAPYEKEVPLSALTNILSAQLISHW 262

Query: 212 PGTMLYLPRGL 222
            G M  LPR L
Sbjct: 263 KGNMTRLPRLL 273



>gi|50513707|pdb|1T5L|B   Chain B, Crystal Structure Of The Dna Repair Protein Uvrb Point
           Mutant Y96a Revealing A Novel Fold For Domain 2
 gi|50513706|pdb|1T5L|A   Chain A, Crystal Structure Of The Dna Repair Protein Uvrb Point
           Mutant Y96a Revealing A Novel Fold For Domain 2
          Length = 658

 Score = 26.2 bits (56), Expect = 8.7
 Identities = 17/72 (23%), Positives = 34/72 (47%), Gaps = 2/72 (2%)

Query: 45  GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDFTD 104
           G  K  T+ NV+A  N P +V+        +  ++     P  A+E++   +  ++   +
Sbjct: 42  GTGKTFTISNVIAQVNKPTLVIAHNKTLAGQLYSELKEFFPHNAVEYFV--SYYDYAQPE 99

Query: 105 LFIPQVRRWIEK 116
            ++PQ   +IEK
Sbjct: 100 AYVPQTDTYIEK 111






  Database: PDB protein database
    Posted date:  Oct 7, 2004 12:08 AM
  Number of letters in database: 4,163,319
  Number of sequences in database:  18,695
  
Lambda     K      H
   0.316    0.133    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,372,139
Number of Sequences: 18695
Number of extensions: 58667
Number of successful extensions: 144
Number of sequences better than 10.0: 7
Number of HSP's better than 10.0 without gapping: 0
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 144
Number of HSP's gapped (non-prelim): 7
length of query: 330
length of database: 4,163,319
effective HSP length: 90
effective length of query: 240
effective length of database: 2,480,769
effective search space: 595384560
effective search space used: 595384560
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)

S2: 56 (26.2 bits)