FUGUE v2.s.07 (01 Apr 2003)
Search sequence(s) against fold library using environment-specific
substitution tables and structure-dependent gap penalties.
Fold library and substitution tables are based on the HOMSTRAD database.
http://www-cryst.bioc.cam.ac.uk/~homstrad/
FUGUE server is available at:
http://www-cryst.bioc.cam.ac.uk/~fugue/
http://www-cryst.bioc.cam.ac.uk/~fugue/prfsearch.html
Citation:
J. Shi, T. L. Blundell and K. Mizuguchi (2001), J Mol Biol, 310(1), 243-57
Size of fold library: 5263
Probe sequence ID : T0257
Probe sequence len : 162
Probe divergence : 0.727
Recommended cutoff : ZSCORE >= 6.0 (CERTAIN 99% confidence)
Other cutoff : ZSCORE >= 4.0 (LIKELY 95% confidence)
Other cutoff : ZSCORE >= 3.5 (MARGINAL 90% confidence)
Other cutoff : ZSCORE >= 2.0 (GUESS 50% confidence)
Other cutoff : ZSCORE < 2.0 (UNCERTAIN)
PLEN : Profile length
RAWS : Raw alignment score
RVN : (Raw score)-(Raw score for NULL model)
ZSCORE : Z-score normalized by sequence divergence
ZORI : Original Z-score (before normalization)
AL : Alignment algorithm used for Zscore/Alignment calculation
0 -- Global, 2 -- GloLocSeq (No sequence termini gap penalty)
3 -- GloLocPrf (No profile termini gap penalty)
The sequence(s) you submitted is HERE (in original format).
The sequence(s) actually used by FUGUE is HERE (in PIR format).
Download all the results in compressed format HERE. new!
View Ranking (Click on a profile hit will bring you to the corresponding HOMSTRAD family)
Profile Hit PLEN RAWS RVN ZSCORE ZORI AL
hs1o7ia 115 -115 36 2.22 5.03 00 GUESS Alignment hs1mm4a 170 -84 42 2.00 4.30 00 GUESS Alignment hsd1mxa_1 101 -100 31 1.74 3.84 02 UNCERTAIN Alignment hs1n10a 228 -228 20 1.68 3.94 00 UNCERTAIN Alignment hs1mwwa 120 -119 38 1.65 4.33 00 UNCERTAIN Alignment hs1owua 245 -212 22 1.49 4.04 03 UNCERTAIN Alignment hs1t1ja 119 -99 47 1.46 2.76 00 UNCERTAIN Alignment hs1g39c 29 -127 23 1.34 2.64 02 UNCERTAIN Alignment rrm 157 -128 38 1.33 4.10 00 UNCERTAIN Alignment hs1b75a 94 -103 24 1.31 3.79 02 UNCERTAIN Alignment
View Alignments (What do they mean -- aa, ma, mh, hh? See note at the bottom of the page.)
Hint: check 'ma' first if your query is a single sequence, otherwise start with 'aa'. Profile Hit HTML POSTSCRIPT TEXT(PIR FORMAT) Confidence View Model Z-score hs1o7ia aa ma mh hh aa ma mh hh aa ma mh hh GUESS PDB Chime 2.22 hs1mm4a aa ma mh hh aa ma mh hh aa ma mh hh GUESS PDB Chime 2.00 hsd1mxa_1 aa ma mh hh aa ma mh hh aa ma mh hh UNCERTAIN PDB Chime 1.74 hs1n10a aa ma mh hh aa ma mh hh aa ma mh hh UNCERTAIN PDB Chime 1.68 hs1mwwa aa ma mh hh aa ma mh hh aa ma mh hh UNCERTAIN PDB Chime 1.65 hs1owua aa ma mh hh aa ma mh hh aa ma mh hh UNCERTAIN PDB Chime 1.49 hs1t1ja aa ma mh hh aa ma mh hh aa ma mh hh UNCERTAIN PDB Chime 1.46 hs1g39c aa ma mh hh aa ma mh hh aa ma mh hh UNCERTAIN PDB Chime 1.34 rrm aa ma mh hh aa ma mh hh aa ma mh hh UNCERTAIN PDB Chime 1.33 hs1b75a aa ma mh hh aa ma mh hh aa ma mh hh UNCERTAIN PDB Chime 1.31Keys
aa: query sequences (including PSI-BLAST homologues) aligned against all the representative structures from a HOMSTRAD family ma: master sequence aligned against all the representative structures from a HOMSTRAD family mh: master sequence aligned against a single structure of highest sequence identity from a HOMSTRAD family hh: single sequence/structure pair with highest sequence identity in 'aa' Note: If your query is a single sequence, master sequence is equivelent to your query and all the other sequences (if any) are collected by PSI-BLAST. If your query is a sequence alignment, master sequence is set to the first sequence in the alignment.JOY Keys are described here
If you have any further questions, please write to Jiye Shi and Kenji Mizuguchi at fugue@cryst.bioc.cam.ac.uk